Xi Cao is doing her master degree in west china School of Nursing, Sichuan University. Her major research interest is nursing management. Xi Cao works under supervison of Ji-Ping Li.
Aims: The aim of this paper is to examine the association between CK level and aggressive behavior in schizophrenic patients.
Methods: A a prospective, observational research was conducted to obtain datafrom 2780patients from January 2009 and December 2013 in the psychiatric ward of theDepartment of Mental Health Center of West China Hospital of SichuanUniversity. The diagnosis of schizophreniawas based on theCCMD-3criterion, and this assessment of patients’ aggression was carried out by the SOAS-R scale. PearsonChi-square test, Kruskal- Wallis H rank sum test, the Pearson product-moment correlation coefficient , multivariate logistic regressionsanalysis and ROC curve wereused to analyze the statistic data.
Results:The rates were 15.9% and 60.5% in the non-aggressive group and aggressive group, respectively, indicating a statistically difference between the two groups(Χ2=1.904, p=0.000). Aggressive behavior was positively associated with creatine kinase (r=0.262,p=0.000). Predictive accuracy was assessed using the AUC of the ROC curve that the outcomes in our study were0.791(95% CI is 0.758 to 0.824), the sensitivity rate is 60.5% and the specificity rate is 84.1%.
Conclusions:In the present research the increased CK levels were consistently associated with patients’ aggression in schizophrenia. CK elevations could be as a predictor of aggression behavior.
Implications: Therefore, high levels of CK should be taken into account in order to staff's attention to the possibility of an increased risk of aggressive behavior. our staff probably dedicated sufficient time to take appropriate precautions to warn other patients, their relatives and employees in clinical practice.