Background: Oral Mucositis (OM) is a common adverse side-effect caused by cancer treatments (chemotherapy and/or radiotherapy). And can lead to mucosa toxicity. Patients with (OM) may experience extreme pain and may not be able to eat, drink and talk and, as a result, their quality of life is impaired. Prevention and management of (OM) in adult patients who received chemotherapy are challenging issues for health care professionals..
Objective: The aim of this study was to evaluate the effect of Cryotherapy on incidence and severity of chemotherapy-induced Oral Mucositis and Oral Mucositis related pain in patients treated with combined chemotherapy (Fluorouracil and Leucovorin) .
Materials and Methods: This study a randomized controlled trial with a random assignment to Cryotherapy and control groups. The study was conducted on 40 cancer patients who underwent chemotherapy .The 20 patients in Cryotherapy group were received instructions for sucking ice cubes in their mouth for five minutes before during and shortly after chemotherapy. The 20 patients in control group received routine care. Oral Mucositis and pain severity were evaluated at 7th, 14th and 21st days of the study after chemotherapy using WHO Mucositis grading and - Numeric Pain Rating Scale.
Results: In The majority of patients in Cryotherapy group .Oral Mucositis was not detected (Grade0) at 7th ,14th and 21st days Similarly incidence of Grade 1and 2 OM in Cryotherapy group significantly lowered when compared with control group where (p< 0.001).Patients in the control group showed significantly higher oral discomfort during the study period (p=0.001).
Conclusion: Oral Cryotherapy due to its simple application, tolerability and lack of side effects makes it a very important resource for reducing the incidence and severity of oral Mucositis and oral Mucositis associated pain. The role of oncology nurses is crucial to the application and success of oral Cryotherapy.