Neuropathic pain is a chronic issue that typically does not resolve. This means that it is experienced for at least three months, or more. The underlying causes that lead to neuropathic pain, many times cannot be cured making the main goal, controlling pain. Prescribers consider quality of life and patient safety when prescribing pharmacologic pain control regimens. They also consider that these patients will need pain control for an extended period, or possibly for the remainder of their life. Risk versus benefit must be considered by all providers. The risks of long-term opioid use are addiction, dependence, and fatal overdose. Most pharmacological pain management options have severe side effects that outweigh any benefits. The provider must choose a safe and effective treatment method with the least amount of side effects and the most amount of pain control. To accurately make this choice, evidence-based research must be gathered on the effects of medicinal cannabis on neuropathic pain. It is important as a provider to be educated on all pain control treatment options. Marijuana is consistently becoming legalized in more states across the US. In patients aged 18 years (P) how does the use of medicinal cannabis (I) compared to opioids (C) influence pain management in those with chronic neuropathic pain (O)?