Nursing is in the midst of revolutionary changes. Many forces are driving changes in Nursing and health care, as health care professional bodies continue to issue new guidelines that influence nursing practices. Nursing includes the promotion of health, prevention of illness, and the care of ill, disabled and dying people. Advocacy, promotion of a safe environment, research participation in shaping health policy and in patient and health system management and education, are also key nursing roles, all these evolved around the nurses as change agents. The foundations of nursing practiced across the world were pioneered by the greatest figure in Nursing history FLORENCE NIGHTINGALE. She helped to define Nursing practice, learned the value of patient observation and good hospital organization, how to care for a patient through the environment. Such practices which significantly reduced mortality at the hospital. The health and survival of human race depends on their ability to adjust to their environment. The unique function of the nurse is to assist the patients towards achieving optimal health. The professional roles are purposeful and directed. This year's theme is apt given the rapidly changing health care situation in our country Nigeria. Health care is growing rapidly as new trends in the Nursing Profession and practice are most appropriate. Also the increasing demand for health care services is a pointer necessary that nurses should strive at the goals of nursing, targeted toward health promotion, maintenance, restoration and supportive functions. We should consider the fact that in developing countries of the world, we are immersed in a global health work force crisis that is characterized by imbalances. The reasons for the crisis are varied and complex. The pandemic has reminded us in the starkest way possible, of the price we pay for weaknesses in health systems, social protection and public services. If nurses fail in their functions, the patient's well-being will be in jeopardy. Now is the time to redouble our efforts to build more inclusive and sustainable economies and societies that are more resilient in the face of pandemics, Climatic change and other global challenges. Pioneering the spirit of enriching the Nursing profession is a matter of enlightened self-interest. At this unusual moment, we cannot resort to the usual tools. Extraordinary times demands extraordinary measures. We face a colossal test, which demands decisive coordinated and innovative action from all, for all.