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6th Edition of Nursing World Conference

October 27-29, 2022 | Orlando, USA

October 27 -29, 2022 | Orlando, Florida, USA
NWC 2016

Raefa Refaat Alam

Speaker at Nursing World Conference 2016 - Raefa Refaat Alam
Mansoura University, Egypt
Title : Effect of sofosbuvir plus ribavirin treatment on quality of life of chronic Hepatitis C patients and its relation to sustained viral response: A pre-post intervention study


Background: Hepatitis C, especially genotype 4 is highly prevalent in Egypt. It is associated with impaired quality of life (QoL). Sofosbuvir (SOF) is now the treatment of choice. The study objective is to compare the QoL score immediately and three months after SOF plus ribavirin treatment with score before treatment in chronic hepatitis C in patients with and without SVR.

Methods: This is a pre-post study carried out in the Egyptian Liver Hospital, Sherbin City, Dakahlia Governorate, Egypt. Data was collected from 38 patients before treatment and QoL scale was re-measured immediately after the end of treatment and three months after treatment during the follow-up visit. They received SOF and ribavirin for 12 weeks. They were retested by PCR for sustained virological response (SVR) three months after completed treatment. The Arabic version of the Short Form-36 (SF-36) scale was used to measure the QoL.

Results: A significant improvement was observed in the total QoLscorein late post compared to pre and early post-treatment (medians were 740 vs. 657.1 and 473.3; respectively) in patients with SVR. This significant improvement was observed in scores of all domains. There is a non-significant improvement in the total QoLscore in late post compared to pre and early post-treatment (medians were 399 vs. 597 and 749; respectively) in non-responders. However, a significant improvement was observed in scores of physical functioning and general health domains only.

Conclusions: In addition to its efficacy and safety SOF improves QoL of HCV patients with SVR.

 Keywords: Sofosbuvir, quality of life, chronic hepatitis C


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