Oncolytic virotherapy represents a groundbreaking frontier in cancer treatment, harnessing viruses to selectively target and destroy cancer cells. This innovative approach holds promise for developing more targeted and less invasive therapies. Ethical considerations in oncolytic virotherapy are paramount, encompassing patient safety in experimental treatments, obtaining informed consent for participation in clinical trials, and addressing potential unintended consequences. The ethical landscape also involves considerations of equitable access to these cutting-edge treatments, transparent communication about potential risks and benefits, and the responsible integration of emerging technologies. As oncolytic virotherapy progresses, ethical frameworks guide researchers and practitioners in ensuring positive contributions to the landscape of cancer care, with a focus on patient welfare and ethical responsibility.