Title : Effectiveness of interventions for pressure ulcers management: A systematic rapid review
Abstract:
Objective:
This study aims at reviewing all randomized controlled trials (RCT) that examine the effectiveness of the various pressure ulcer therapies.
Background:
Pressure ulcers are a prevalent problem in bedridden patients, causing them severe pain and discomfort. Therapy modalities for span a wide range of options, from dressings to mattresses and passing by nutritional supplementations, among many others.
Inclusion criteria:
All RCTs published between 2008 and 2022 in English were considered eligible for inclusion if they aimed at examining the effectiveness of a therapy modality for pressure ulcers management.
Methods:
This is a rapid systematic review conducted according to the JBI SUMARI methodology. The databases searched are Medline, CINAHL, and Scopus. Duplicates will be removed using EndNote20. JBI summary was used for screening, appraisal, and extraction.
Results:
nterventions that improve healing if added to standard care include topical Semelil (ANGIPARS™) 3% gel, topical atorvastatin 1% ointment, small intestinal submucosa extracellular matrix, nutritional supplementations, high voltage electrical stimulation, polarized light therapy, transdermal wound oxygen therapy, wheelchairs with an individually adjusted automated seat that provides cyclic pressure relief, and Intramuscular intervention of 3 ml, 5.625 mg Polydeoxyribonucleotides. Ineffective intervention includes oral anabolic steroids and sucralfate gel—no difference between silver mesh and cream, nor between Thai herbal oil and standard dressings. ATRAUMAN Ag (silver ions) dressing is better than paraffin gauze BACTIGRAS. Two doses of PRGF+ hyaluronic acid are better than one dose.
Conclusion:
Studies comparing the effectiveness of different modalities and reviews aiming at ranking the effectiveness of all of these modalities are needed to help better understand the cost to value ratio of these interventions.
Keywords:
Pressure ulcer, bedsore, chronic wound, treatment, management, randomized controlled trials
Audience Take Away Notes:
- This rapid review gives an excellent overview of the latest treatments available for pressure ulcers worldwide and their effectiveness
- Allows healthcare professionals to make comparisons and inform evidence-based decision-making.
- The results of this study are crucial to upgrading and enhancing the treatment protocols for pressure ulcers.
